Price range: $75.00 through $299.00

Product Information:

Name:?N-Acetyl Semax Amidate; Ac-Semax Amidate; Ac-Semax-NH2
CAS No.: N/A
Peptide Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
Appearance: White Lyophilized powder

 

🧬 N-Acetyl Semax Amidate (NA-Semax-Amidate): Structure, Mechanisms & Research Uses

Overview

N-Acetyl Semax Amidate (NA-Semax-Amidate) is an advanced synthetic peptide belonging to the Semax family of neuroactive heptapeptides. Designed with both N-terminal acetylation and C-terminal amidation, this modified structure offers improved molecular stability and enhanced resistance to enzymatic degradation, making it well suited for experimental and biochemical research.

Its refined chemical profile allows researchers to examine neuroregulatory pathways and peptide behavior under controlled laboratory conditions.


Molecular Profile and Chemical Characteristics

  • Peptide Name: N-Acetyl-Pro-Gly-Pro-Gly-Pro-His-Pro-NH₂
  • Alternate Names: NA-Semax-Amidate, Ac-Semax-NH₂
  • Molecular Formula: C₃₇H₅₆N₁₀O₉
  • Molecular Weight: ~796.9 g/mol
  • Peptide Class: Synthetic heptapeptide
  • Form: Lyophilized research-grade powder

The combined acetylation and amidation modifications significantly enhance peptide durability, supporting prolonged stability during in-vitro and in-vivo experimental work.


Development Background

Semax-based peptides were originally developed through neuropeptide research programs aimed at modeling fragments of ACTH (4–10) and their effects on neural signaling. NA-Semax-Amidate was later engineered as a more structurally resilient analogue, allowing researchers to explore neurochemical activity with greater experimental consistency.

This enhanced version provides a dependable platform for studying peptide behavior, signaling pathways, and neuroregulatory mechanisms.


Areas of Research Interest

Although not approved for therapeutic or dietary use, NA-Semax-Amidate is actively explored in preclinical research environments. Key investigative areas include:

1. Neurotrophic Signaling Modulation

Related Semax analogs have demonstrated potential involvement in pathways associated with BDNF and NGF, which play essential roles in neuronal growth and maintenance.

2. Neuroprotection and Stress Response

Researchers study Semax-type peptides for their influence on oxidative balance, antioxidant enzyme activity, and adaptive cellular responses under stress conditions.

3. Learning and Synaptic Plasticity Models

Experimental models suggest that Semax derivatives may affect neurotransmission and synaptic efficiency, positioning NA-Semax-Amidate as a useful tool for cognitive mechanism research.


Research Applications

N-Acetyl Semax Amidate is commonly used in laboratory studies to examine:

  • Peptide stabilization and degradation pathways
  • Neuroactive peptide transport mechanisms
  • Peptide–receptor interaction dynamics
  • Molecular signaling involved in neurochemical regulation

Its enhanced chemical stability makes it especially suitable for experimental models requiring sustained peptide exposure.


Storage, Handling & Safety Information

  • Physical Form: Lyophilized powder
  • Recommended Storage: −20 °C
  • Solubility: Water, saline, or neutral buffer
  • Shelf Life: Up to 24 months under appropriate conditions
  • Purity: ≥98% (supplier dependent)

⚠️ Research Use Only:
NA-Semax-Amidate is intended strictly for laboratory research. It is not approved for human, veterinary, or medical use. All handling must comply with institutional safety standards and regulatory guidelines.


Regulatory Status

N-Acetyl Semax Amidate is classified as a research-use-only (RUO) compound. It has not received approval from regulatory authorities such as the FDA, EMA, or TGA. Distribution and use must remain confined to non-clinical research settings.


Summary

N-Acetyl Semax Amidate represents a refined evolution of Semax peptide research, offering enhanced molecular stability and experimental reliability. Its structural modifications provide researchers with a robust model for investigating neurochemical signaling, peptide engineering, and structure-function relationships in synthetic heptapeptides.

By examining compounds like NA-Semax-Amidate, scientists can better understand how targeted chemical modifications influence peptide behavior and biological activity at the molecular level.